![]() Mice are the most frequently cited animal model in biomedical publications (Table 1). Some of the interesting mouse models are discussed later in this article. The aforementioned animal models are used for research in immunology, oncology, physiology, pathology, and increasingly, neuroscience. The majority of these animals are supplied by four major providers, The Jackson Laboratory, Charles River Laboratories, Taconic Biosciences and Harlan Laboratories. Other strains, such as A/J mice, CD1 mice, and ICR mice, were also used. The survey results indicate that mouse is the overwhelmingly preferred laboratory animal the most widely used mouse and rat strains are C57BL/6 mice, BALB/c mice, Sprague-Dawley rats and Wistar rats. Labome has surveyed formal publications citing animal models to provide an overview of animal models in publications (Table 1). ![]() Labome surveys literature for instruments and reagents. The genomes of the major model organisms have been sequenced, verifying a high level of genetic conservation among model organisms and humans. Today they are indispensable in biomedical research contributing to our understanding of the functions of genes, the etiology and mechanisms of different diseases, and the effectiveness and the toxicities of medicines and chemicals. Animal models have been critical tools since the early days of scientific discovery.
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